Rotavirus A

The rotavirus genome consists of 11 segments of double-stranded RNA surrounded by a double-shelled viral capsid. When examined by electron microscopy, the double-shelled particles resemble a wheel-like structure morphologically. Rotaviruses are classified with the Reoviridae family. They have a genome consisting of 11 double-stranded RNA segments surrounded by a distinctive two-layered protein capsid. Six serological groups have been identified, three of which (groups A, B, and C) infect humans. Rotavirus is endemic worldwide. It is the leading cause of severe diarrhoea mainly in infants and children, and accounts for about half of the cases requiring hospitalisation. In temperate areas, it occurs primarily in the winter, but in the tropics it occurs throughout the year.

Characteristics
Shape and Size
80- 70nm. icosahedral,
Genome Information
Rotavirus A is a positive-strand viruses ( GI:-604632664) has a 700 bp double stranded linear RNA.The genome structure consists of 1 genes and 1 proteins.The GC content of Rotavirus A is about 38.1%.
Food Source
lettuce ,raddish carrot,flitered fruit juice
Pathological Factor
Usually, children under the age of 3 are susceptible to group A rotavirus infections. Group B rotaviruses primarily cause epidemics of severe diarrhoea in adults .The target cells of rotaviruses are differentiated enterocytes in the small intestine, near the tips of the villi.The infective dose in human beings is probably 10-100 infectious viral particles.A person with rotavirus diarrhoea often excretes large numbers of viruses: 108-1010 .infectious particles/ml of faeces.
Disease
acute gastroenteritis. Infantile diarrhoea, winter diarrhoea, acute nonbacterial infectious gastroenteritis
Symptoms
It results in a high burden of disease in all countries and is an important cause of death through dehydration in developing countries. Symptoms may persist for several days or longer, leading to dehydration ,vomiting, watery diarrhoea and low-grade fever.
Affected Body Organs
gastro intestinal organs

Classification
Group Group-III-(dsRNA)
Order Unassigned
Family Reoviridae
Subfamily Sedoreovirinae
Genus Rotavirus
Species Rotavirus A