PROTEOBACTERIA >> Beta >> Bordetella >> Bordetella pertussis
BORDETELLA PERTUSSIS
| Class: | Beta Proteobacteria |
| Genus: | Bordetella |
| Species: | Bordetella pertussis |
| Description: | Bordetella pertussis is a Gram-negative, aerobic, pathogenic, encapsulated coccobacillus of the genus Bordetella, and the causative agent of pertussis or whooping cough. Unlike B. bronchiseptica, B. pertussis is not motile. Its virulence factors include pertussis toxin, filamentous hæmagglutinin, pertactin, fimbria, and tracheal cytotoxin.B. pertussis has the ability to inhibit the function of the host's immune system. The toxin, known as pertussis toxin (or PTx), inhibits G protein coupling that regulates an adenylate cyclase-mediated conversion of ATP to cyclic AMP. The end result is phagocytes convert too much ATP to cyclic AMP, which can cause disturbances in cellular signaling mechanisms, and prevent phagocytes from correctly responding to an infection. |
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| Source: | |
| Pathogenicity: | Infection of the respiratory system. |
| Genbank: | NC_002929.2 [Genome] [Nucleotide] |
| Size (Mb): | 4.09 |
| GC %: | 67.7 |
| Genes: | 3,85 |
| CDS Number: | |
| Reference: | Nieves DJ, Heininger U (2016). "Bordetella pertussis". Microbiology Spectrum. 4 (3). doi:10.1128/microbiolspec.EI10-0008-2015. PMID 27337481. |
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