PROTEOBACTERIA >> Gamma >> Haemophilus >> Haemophilus ducreyi
HAEMOPHILUS DUCREYI
| Class: | Gamma Proteobacteria |
| Genus: | Haemophilus |
| Species: | Haemophilus ducreyi |
| Description: | Gram negative, 0.5/1,5-2.0 μm, slender rods in pairs or chains ; “school of fish”-like arrangements. Capsules have not been detected. Fine tangled pili composed of a unique major protein subunit of 24 kDa.Colonies on chocolate agar are smooth, flat, grayish, translucent, small (0.5 mm in diameter) after 72 h. , but often with a few interspersed larger colonies having an otherwise identical appearance. Hemolysis is variable.Aerobic, facultatively anaerobic, require X-factor but not V-factor for growth. CO2 requirement is variable. |
| Synonyms: | Bacillus ulceris cancrosi Kruse 1896, "Coccobacillus ducreyi" Neveu-Lemaire 1921. |
| Source: | Isolated from humans suffering of venereal disease “soft chancre “ or “chancroid”. |
| Pathogenicity: | This organism is an obligate human pathogen that causes the sexually transmitted disease chancroid (ulcer of the genital region) and it enhances the transmission of HIV (which enhances Haemophilus ducreyi transmission in turn). This organism is an apparent extracellular pathogen that resists phagocytosis. Some of the virulence factors include an outer membrane serum resistance protein, as well as two toxins, cytolethal distending toxin (CDT) and hemolysin, both of which contribute to tissue destruction. |
| Genbank: | NC_002940.2 [Genome] [Nucleotide] |
| Size (Mb): | 1.7 |
| GC %: | 38.2 |
| Genes: | 1,668 |
| CDS Number: | 1,509 |
| Reference: | Mogens Kilian, 2004.Genus III. Haemophilus . In: Bergey’s Manual of Systematic Bacteriology, Second edition,Vol two, part B, George M. Garrity (Editor-in-Chief), pp. 883-904,,Mary P.E. Slack, 2006.Haemophilus. In: Topley & Wilson’s Microbiology and Microbial Infections, 10 edition, Vol. 2, Bacteriology, Edward Arnold Ltd.,,J. G.Holt et al., 1994.Begey’s manual of Determinative Bacteriology, 9-edition, Williams & Wilkins . |
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