PROTEOBACTERIA >> Gamma >> Mannheimia >> Mannheimia haemolytica
MANNHEIMIA HAEMOLYTICA
| Class: | Gamma Proteobacteria |
| Genus: | Mannheimia |
| Species: | Mannheimia haemolytica |
| Description: | Cells are Gram-negative, non-motile small rods and coccobacilli. Colonies are smooth and greyish on blood agar and are 1-2 mm in diameter after 24 h incubation. Most strains show a characteristic β-haemolysis on bovine blood agar. |
| Synonyms: | |
| Source: | The type strain isolated from sheep in the UK in 1956. |
| Pathogenicity: | Causing major respiratory infections in feedlot cattle and other ruminants. The result is the loss of over a billion dollars to the cattle industry each year as the organism can infect up to one percent of feedlot animals, with an increase in morbidity, but also a decrease in weight gain. One of the major virulence factors is leukotoxin, which binds to ruminant leukocytes, inserting a pore into the membrane, and inducing necrosis and cell death. Other virulence factors including lipopolysaccharide, an endotoxin, and capsular polysaccharide, which aids in evasion of host immune defenses. This strain is a serotype 1 strain isolated from an infected calf. |
| Genbank: | NC_021082.1 [Genome] [Nucleotide] |
| Size (Mb): | 2.73 |
| GC %: | 41 |
| Genes: | 2,773 |
| CDS Number: | 2,633 |
| Reference: | ANGEN (Ø), MUTTERS (R.), CAUGANT (D.A.), OLSEN (J.E.) and BISGAARD (M.): Taxonomic relationships of the [Pasteurella] haemolytica complex as evaluated by DNA-DNA hybridizations and 16S rRNA sequencing with proposal of Mannheimia haemolytica gen. nov., comb. nov., Mannheimia granulomatis comb. nov., Mannheimia glucosida sp. nov., Mannheimia ruminalis sp. nov. and Mannheimia varigena sp. nov. Int. J. Syst. Bacteriol., 1999, 49, 67-86. |
| Biochemical Tests: |